Assessment of optimal sampling times for estimation of AUC in Therapeutic Drug Monitoring by Monte Carlo simulations
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چکیده
The aim of the procedure is to determine the optimal sampling times for the assessment of AUC after administration of a drug, either as a single dose or during a regular dosing schedule. For a single dose, AUC is defined as the total area under the plasma concentration time profile from time zero to infinity; for a regular dosing interval at steady state, AUC is defined as the area under the plasma concentration time profile over one dosing interval of duration . Assuming linear pharmacokinetics, AUC equals Dose/CL for an intravenous administration, and Dose.F/CL for an extravascular administration.
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